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The dipeptide cysteine-glycine is degraded by the enzyme cysteine-glycine dipeptidase found on the cell membrane [50]

10.1073/pnas.0601416103 Proc

10.1128/mbio.03404-22

Although numerous topical and systemic therapeutic agents and also non-pharmacologic procedural treatments have been considered in melasma management, however, the commonly available therapeutic options have several limitations including the lack of sufficient clinical effectiveness, risk of relapse, and high rate of unwanted adverse drug reactions